Looking at the other answers to your question I noticed that they told you how to do what you are trying to do, but they did not answer the question you posed at the end.
If the input query is "What is Hello", I get the output as:
wht s llo
Why does this happen?
This happens because .replace() replaces the substring you give it exactly.
for example:
"My, my! Hello my friendly mystery".replace("my", "")
gives:
>>> "My, ! Hello friendly stery"
.replace() is essentially splitting the string by the substring given as the first parameter and joining it back together with the second parameter.
"hello".replace("he", "je")
is logically similar to:
"je".join("hello".split("he"))
If you were still wanting to use .replace to remove whole words you might think adding a space before and after would be enough, but this leaves out words at the beginning and end of the string as well as punctuated versions of the substring.
"My, my! hello my friendly mystery".replace(" my ", " ")
>>> "My, my! hello friendly mystery"
"My, my! hello my friendly mystery".replace(" my", "")
>>> "My,! hello friendlystery"
"My, my! hello my friendly mystery".replace("my ", "")
>>> "My, my! hello friendly mystery"
Additionally, adding spaces before and after will not catch duplicates as it has already processed the first sub-string and will ignore it in favor of continuing on:
"hello my my friend".replace(" my ", " ")
>>> "hello my friend"
For these reasons your accepted answer by Robby Cornelissen is the recommended way to do what you are wanting.