You can use generator expression to find the maximum in your matrix. That way you can avoid building the full list of matrix elements in memory.
maximum = max(max(row) for row in matrix)
instead of list comprehension as given in a previous answer here
maximum = max([max(row) for row in matrix])
This is from PEP (the rationale section):
...many of the use cases do not need to have a full list created in
memory. Instead, they only need to iterate over the elements one at a
time.
...
Generator expressions are especially useful with functions like sum(), min(), and max() that reduce an iterable input to a single value
...
The utility of generator expressions is greatly enhanced when combined with reduction functions like sum(), min(), and max().
Also, take a look at this SO post: Generator Expressions vs. List Comprehension.