Is it possible that you installed those particular packages with pip? If so, then the mangled directories are probably the temporary directories that pip creates when it uninstalls a package (or when it uninstalls a package in preparation for updating a package).
I dug through the pip source code and found this snippet which is evidently only used on uninstalling packages:
class AdjacentTempDirectory(TempDirectory):
"""Helper class that creates a temporary directory adjacent to a real one.
Attributes:
original
The original directory to create a temp directory for.
path
After calling create() or entering, contains the full
path to the temporary directory.
delete
Whether the directory should be deleted when exiting
(when used as a contextmanager)
"""
# The characters that may be used to name the temp directory
# We always prepend a ~ and then rotate through these until
# a usable name is found.
# pkg_resources raises a different error for .dist-info folder
# with leading '-' and invalid metadata
LEADING_CHARS = "-~.=%0123456789"
...
If that's what these files are, then you can safely delete them.