As noted by others, it would be very difficult to keep the up-to-date database of all letters in all existing languages. But in most cases you don't actually need that and it can be perfectly fine for your code to begin by supporing just several chosen languages and adding others as needed.
The following simple code supports matching for Czech, German and Polish language. The character sets can be easily obtained from Wikipedia.
import re
LANGS = [
'ÁáČčĎďÉéĚěÍíŇňÓóŘřŠšŤťÚúŮůÝýŽž', # Czech
'ÄäÖöÜüẞß', # German
'ĄąĆćĘꣳŃńÓóŚśŹźŻż', # Polish
]
pattern = '[A-Za-z{langs}]'.format(langs=''.join(LANGS))
pattern = re.compile(pattern)
result = pattern.findall('Žluťoučký kůň')
print(result)
# ['Ž', 'l', 'u', 'ť', 'o', 'u', 'č', 'k', 'ý', 'k', 'ů', 'ň']