LCAT
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesLCAT, entrez:3931, lecithin-cholesterol acyltransferase
External IDsOMIM: 606967 MGI: 96755 HomoloGene: 68042 GeneCards: LCAT
Orthologs
SpeciesHumanMouse
Entrez

3931

16816

Ensembl

ENSG00000213398

ENSMUSG00000035237

UniProt

P04180

P16301

RefSeq (mRNA)

NM_000229

NM_008490

RefSeq (protein)

NP_000220

NP_032516

Location (UCSC)Chr 16: 67.94 – 67.94 MbChr 8: 106.67 – 106.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lecithin–cholesterol acyltransferase (LCAT, also called phosphatidylcholine–sterol O-acyltransferase) is an enzyme, in many animals including humans, that converts free cholesterol into cholesteryl ester (a more hydrophobic form of cholesterol), which is then sequestered into the core of a lipoprotein particle, eventually making the newly synthesized HDL spherical and forcing the reaction to become unidirectional since the particles are removed from the surface. The enzyme is bound to high-density lipoproteins (HDLs) (alpha-LCAT) and LDLs (beta-LCAT) in the blood plasma.[5] LCAT deficiency can cause impaired vision due to cholesterol corneal opacities, anemia, and kidney damage.[6] It belongs to the family of phospholipid:diacylglycerol acyltransferases.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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Statin_Pathway_WP430
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Statin_Pathway_WP430
|alt=Statin Pathway edit]]
Statin Pathway edit
  1. The interactive pathway map can be edited at WikiPathways: "Statin_Pathway_WP430".

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000213398 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035237 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Lecithin-Cholesterol Acyltransferase Deficiency: Overview, Presentation, Differential Diagnosis". 2016-08-08. {{cite journal}}: Cite journal requires |journal= (help)
  6. Reference, Genetics Home. "LCAT gene". Genetics Home Reference. Retrieved 2016-12-11.

Further reading


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