TIE1
Identifiers
AliasesTIE1, JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11
External IDsOMIM: 600222 MGI: 99906 HomoloGene: 3957 GeneCards: TIE1
Orthologs
SpeciesHumanMouse
Entrez

7075

21846

Ensembl

ENSG00000066056

ENSMUSG00000033191

UniProt

P35590

Q06806

RefSeq (mRNA)

NM_001253357
NM_005424

NM_011587

RefSeq (protein)

NP_001240286
NP_005415

NP_035717

Location (UCSC)Chr 1: 43.3 – 43.32 MbChr 4: 118.33 – 118.35 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
SymbolTIE1
Alt. symbolsTIE, JTK14
NCBI gene7075
HGNC11809
OMIM600222
RefSeqNM_005424
UniProtP35590
Other data
EC number2.7.1.112
LocusChr. 1 p34-p33
Search for
StructuresSwiss-model
DomainsInterPro

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene.[5]

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells[6] and platelets.[7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis.[8]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000066056 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033191 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC 369613. PMID 1312667.
  6. Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID 8570217.
  7. Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID 11146396. S2CID 43509019.
  8. Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID 18448073.
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