The _ and % characters have to be quoted to be matched literally in a LIKE statement, there's no way around it. The choice is about doing it client-side, or server-side (typically by using the SQL replace(), see below). Also to get it 100% right in the general case, there are a few things to consider.
By default, the quote character to use before _ or % is the backslash (\), but it can be changed with an ESCAPE clause immediately following the LIKE clause.
In any case, the quote character has to be repeated twice in the pattern to be matched literally as one character.
Example: ... WHERE field like 'john^%node1^^node2.uucp@%' ESCAPE '^'
would match john%node1^node2.uccp@ followed by anything.
There's a problem with the default choice of backslash: it's already used for other purposes when standard_conforming_strings is OFF (PG 9.1 has it ON by default, but previous versions being still in wide use, this is a point to consider).
Also if the quoting for LIKE wildcard is done client-side in a user input injection scenario, it comes in addition to to the normal string-quoting already necessary on user input.
A glance at a go-pgsql example tells that it uses $N-style placeholders for variables... So here's an attempt to write it in a somehow generic way: it works with standard_conforming_strings both ON or OFF, uses server-side replacement of [%_], an alternative quote character, quoting of the quote character, and avoids sql injection:
db.Query("SELECT * from USERS where name like replace(replace(replace($1,'^','^^'),'%','^%'),'_','^_') ||'%' ESCAPE '^'",
variable_user_input);