Answering my own question:
Seeds
From the FAQ:
Seeds are used during startup to discover the cluster.
Also from the DataStax documentation on "Gossip":
The seed node designation has no purpose other than bootstrapping the gossip process
for new nodes joining the cluster. Seed nodes are not a single
point of failure, nor do they have any other special purpose in
cluster operations beyond the bootstrapping of nodes.
From these details it seems that a seed is nothing special to clients.
Clients
From the DataStax documentation on client requests:
All nodes in Cassandra are peers. A client read or write request can
go to any node in the cluster. When a client connects to a node and
issues a read or write request, that node serves as the coordinator
for that particular client operation.
The job of the coordinator is to act as a proxy between the client
application and the nodes (or replicas) that own the data being
requested. The coordinator determines which nodes in the ring should
get the request based on the cluster configured partitioner and
replica placement strategy.
I gather that the pool of nodes that a client connects to can just be a handful of (random?) nodes in the DC to allow for potential failures.