There are many issues. Extrapolation is a nasty thing to start with. Do you assume a linear extrapolant? Polynomial models (beyond linear) extrapolate terribly poorly in general. Or should you assume some sort of extrapolant that is asymptotic to a line? What matters is what you are willing to assume, and what information you can bring to the modeling process.
If you can assume a linear extrapolant, then I might do a weighted least squares fit, with a straight line model with decreasing weights as you move away from the endpoint. (In fact, no matter what model you end up posing, a weighted least squares estimation seems logical, with the weights a function of position.)
Thus, suppose you choose to pose a nonlinear model that is something like
y = a + bx + c*exp(-d*x)
This model will asymptotically approach a straight line, with slope b, as x gets large. You might still use a weighted model that discounts those points away from the end you are interested in.
Again, long distance extrapolation is a difficult thing to attempt. Remember the words of Mark Twain...
“In the space of one hundred and seventy six years the Lower Mississippi has shortened itself two hundred and forty-two miles. That is an average of a trifle over a mile and a third per year. Therefore, any calm person, who is not blind or idiotic, can see that in the Old Oölitic Silurian Period, just a million years ago next November, the Lower Mississippi was upwards of one million three hundred thousand miles long, and stuck out over the Gulf of Mexico like a fishing-pole. And by the same token any person can see that seven hundred and forty-two years from now the Lower Mississippi will be only a mile and three-quarters long, and Cairo [Illinois] and New Orleans will have joined their streets together and be plodding comfortably along under a single mayor and a mutual board of aldermen. There is something fascinating about science. One gets such wholesale returns of conjecture out of such a trifling investment of fact.”
"Life on the Mississippi", Mark Twain, 1884