This is a funky one. And I'm sure it's webkit related since it only seems to be an issue in Chrome Version 20.0.1132.57 and Safari 5.1.7. I've uploaded a short video to explain the issue because it would be nearly impossible to explain via text.
Video: http://youtu.be/0XttO-Diz2g
Short version: During CSS3 animations, text that is inside a positioned element (absolute or relative) seems to change its antialiasing. It becomes bolder while animations are running.
Note: This is not the same as scaled elements becoming blurry diring an animation. (this issue)
Any thoughts, workarounds, etc?