This sentence is here to help me reach the 30 character minimum. Ignore this and read the next sentence for your answer:
No.
UPDATE:
"Changing" and "Redirecting" are two different things. You need to clarify which it is. "Changing" the address bar is impossible.
"Redirecting" IS possible.
Clicking on a standard link from within an iframe will not affect the topmost window on its own. A quick example of a Javascript redirect within an iframe would be something like this:
TOP WINDOW:
<html>
<head></head>
<body>
<iframe src="http://yoursite.com/iframe_test.html" />
</body>
IFRAME TEST:
<html>
<head>
<script>
window.onload = ready;
function ready()
{
document.getElementById("link1").onclick = linkClick;
document.getElementById("link2").onclick = linkClick;
}
function linkClick(e)
{
e.preventDefault();
window.top.location.href = this.href;
}
</script>
</head>
<body>
<a id="link1" href="http://youtube.com">Link1</a>
<a id="link2" href="http://facebook.com">Link2</a>
</body>
EXPLANATION:
Without the Javascript in place, what will happen when you click on a link in an iframe is that you will remain on the original page and the iframe will be redirected to the link you've clicked on. Using Javascript within an iframe in this fashion can force the topmost frame to redirect.
I would highly discourage relying on this in any way. It's sloppy programming in general, and I would stay away from iframes altogether if possible.