I don't think it is possible to prevent a mouse click via C# .Net. However, you might be able to lock the mouse pointer in one position via ClipCursor. The below link may help you with that.
If you essentially want to prevent one mouse from being used why not just disable the mouse like you could if you went to device manager and clicked "disable". This can be done programmatically as solved here.
Here is the code copied from the link above:
public static class DisableHardware
{
const uint DIF_PROPERTYCHANGE = 0x12;
const uint DICS_ENABLE = 1;
const uint DICS_DISABLE = 2; // disable device
const uint DICS_FLAG_GLOBAL = 1; // not profile-specific
const uint DIGCF_ALLCLASSES = 4;
const uint DIGCF_PRESENT = 2;
const uint ERROR_INVALID_DATA = 13;
const uint ERROR_NO_MORE_ITEMS = 259;
const uint ERROR_ELEMENT_NOT_FOUND = 1168;
static DEVPROPKEY DEVPKEY_Device_DeviceDesc;
static DEVPROPKEY DEVPKEY_Device_HardwareIds;
[StructLayout(LayoutKind.Sequential)]
struct SP_CLASSINSTALL_HEADER
{
public UInt32 cbSize;
public UInt32 InstallFunction;
}
[StructLayout(LayoutKind.Sequential)]
struct SP_PROPCHANGE_PARAMS
{
public SP_CLASSINSTALL_HEADER ClassInstallHeader;
public UInt32 StateChange;
public UInt32 Scope;
public UInt32 HwProfile;
}
[StructLayout(LayoutKind.Sequential)]
struct SP_DEVINFO_DATA
{
public UInt32 cbSize;
public Guid classGuid;
public UInt32 devInst;
public IntPtr reserved; // CHANGE #1 - was UInt32
}
[StructLayout(LayoutKind.Sequential)]
struct DEVPROPKEY
{
public Guid fmtid;
public UInt32 pid;
}
[DllImport("setupapi.dll", SetLastError = true)]
static extern IntPtr SetupDiGetClassDevsW(
[In] ref Guid ClassGuid,
[MarshalAs(UnmanagedType.LPWStr)]
string Enumerator,
IntPtr parent,
UInt32 flags);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiDestroyDeviceInfoList(IntPtr handle);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiEnumDeviceInfo(IntPtr deviceInfoSet,
UInt32 memberIndex,
[Out] out SP_DEVINFO_DATA deviceInfoData);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiSetClassInstallParams(
IntPtr deviceInfoSet,
[In] ref SP_DEVINFO_DATA deviceInfoData,
[In] ref SP_PROPCHANGE_PARAMS classInstallParams,
UInt32 ClassInstallParamsSize);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiChangeState(
IntPtr deviceInfoSet,
[In] ref SP_DEVINFO_DATA deviceInfoData);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiGetDevicePropertyW(
IntPtr deviceInfoSet,
[In] ref SP_DEVINFO_DATA DeviceInfoData,
[In] ref DEVPROPKEY propertyKey,
[Out] out UInt32 propertyType,
IntPtr propertyBuffer,
UInt32 propertyBufferSize,
out UInt32 requiredSize,
UInt32 flags);
[DllImport("setupapi.dll", SetLastError = true)]
static extern bool SetupDiGetDeviceRegistryPropertyW(
IntPtr DeviceInfoSet,
[In] ref SP_DEVINFO_DATA DeviceInfoData,
UInt32 Property,
[Out] out UInt32 PropertyRegDataType,
IntPtr PropertyBuffer,
UInt32 PropertyBufferSize,
[In,Out] ref UInt32 RequiredSize
);
static DisableHardware()
{
DisableHardware.DEVPKEY_Device_DeviceDesc = new DEVPROPKEY();
DEVPKEY_Device_DeviceDesc.fmtid = new Guid(
0xa45c254e, 0xdf1c, 0x4efd, 0x80, 0x20, 0x67,
0xd1, 0x46, 0xa8, 0x50, 0xe0);
DEVPKEY_Device_DeviceDesc.pid = 2;
DEVPKEY_Device_HardwareIds = new DEVPROPKEY();
DEVPKEY_Device_HardwareIds.fmtid = new Guid(
0xa45c254e, 0xdf1c, 0x4efd, 0x80, 0x20, 0x67,
0xd1, 0x46, 0xa8, 0x50, 0xe0);
DEVPKEY_Device_HardwareIds.pid = 3;
}
public static void DisableDevice(Func<string, bool> filter, bool disable = true)
{
IntPtr info = IntPtr.Zero;
Guid NullGuid = Guid.Empty;
try
{
info = SetupDiGetClassDevsW(
ref NullGuid,
null,
IntPtr.Zero,
DIGCF_ALLCLASSES);
CheckError("SetupDiGetClassDevs");
SP_DEVINFO_DATA devdata = new SP_DEVINFO_DATA();
devdata.cbSize = (UInt32)Marshal.SizeOf(devdata);
// Get first device matching device criterion.
for (uint i = 0; ; i++)
{
SetupDiEnumDeviceInfo(info,
i,
out devdata);
// if no items match filter, throw
if (Marshal.GetLastWin32Error() == ERROR_NO_MORE_ITEMS)
CheckError("No device found matching filter.", 0xcffff);
CheckError("SetupDiEnumDeviceInfo");
string devicepath = GetStringPropertyForDevice(info,
devdata, 1); // SPDRP_HARDWAREID
// Uncomment to print name/path
//Console.WriteLine(GetStringPropertyForDevice(info,
// devdata, DEVPKEY_Device_DeviceDesc));
//Console.WriteLine(" {0}", devicepath);
if (devicepath != null && filter(devicepath)) break;
}
SP_CLASSINSTALL_HEADER header = new SP_CLASSINSTALL_HEADER();
header.cbSize = (UInt32)Marshal.SizeOf(header);
header.InstallFunction = DIF_PROPERTYCHANGE;
SP_PROPCHANGE_PARAMS propchangeparams = new SP_PROPCHANGE_PARAMS();
propchangeparams.ClassInstallHeader = header;
propchangeparams.StateChange = disable ? DICS_DISABLE : DICS_ENABLE;
propchangeparams.Scope = DICS_FLAG_GLOBAL;
propchangeparams.HwProfile = 0;
SetupDiSetClassInstallParams(info,
ref devdata,
ref propchangeparams,
(UInt32)Marshal.SizeOf(propchangeparams));
CheckError("SetupDiSetClassInstallParams");
SetupDiChangeState(
info,
ref devdata);
CheckError("SetupDiChangeState");
}
finally
{
if (info != IntPtr.Zero)
SetupDiDestroyDeviceInfoList(info);
}
}
private static void CheckError(string message, int lasterror = -1)
{
int code = lasterror == -1 ? Marshal.GetLastWin32Error() : lasterror;
if (code != 0)
throw new ApplicationException(
String.Format("Error disabling hardware device (Code {0}): {1}",
code, message));
}
private static string GetStringPropertyForDevice(IntPtr info, SP_DEVINFO_DATA devdata,
uint propId)
{
uint proptype, outsize;
IntPtr buffer = IntPtr.Zero;
try
{
uint buflen = 512;
buffer = Marshal.AllocHGlobal((int)buflen);
outsize=0;
// CHANGE #2 - Use this instead of SetupDiGetDeviceProperty
SetupDiGetDeviceRegistryPropertyW(
info,
ref devdata,
propId,
out proptype,
buffer,
buflen,
ref outsize);
byte[] lbuffer = new byte[outsize];
Marshal.Copy(buffer, lbuffer, 0, (int)outsize);
int errcode = Marshal.GetLastWin32Error();
if (errcode == ERROR_INVALID_DATA) return null;
CheckError("SetupDiGetDeviceProperty", errcode);
return Encoding.Unicode.GetString(lbuffer);
}
finally
{
if (buffer != IntPtr.Zero)
Marshal.FreeHGlobal(buffer);
}
}
}
http://msdn.microsoft.com/en-us/library/windows/desktop/ms648383%28v=vs.85%29.aspx
http://www.pinvoke.net/default.aspx/user32/ClipCursor.html