Combating a smart scripter is tough. They have the upper hand since their script can touch the page before your server does, and can block or replace just about anything. See this answer to a very similar question.
Your smartest, and most cost-effective countermeasure is to sanction the users who are "gaming" the game. Attack the burglar, not the lock-pick.
If you insist in a tech war with your users, nothing you do will block everybody, but you can make them work for it.
Here are some things you can do make life harder for scripters:
Frequently change the structure of the page, especially element ID's and CSS class names. If you can, periodically insert or remove elements, so that the key <div>
is not always the 3rd one in the second <table>
, for example.
Every time you make a change, monitor your logs for users who get a sudden decrease in performance or usage -- for however many hours or days it takes them to adapt their scripts.
Likewise, frequently change your javascript filenames, and change the names of any variables or functions that the scripter may use.
Write your click and keyboard event-handlers to only work for trusted events, for browsers that support it.
You can put key text, including countdown timers, in images with unpredictable names. Making it hard for the script to detect key events. Needing to do OCR ramps up the skill-level required by a Greasemonkey scriptwriter, considerably. (At least for now.)
If you move the key game action into Flash, it becomes an order of magnitude harder to script for. They may even have to reverse engineer your flash and replace it with one that has scriptable hooks. Switching to Flash will annoy and drive off users (like me), though.
See that answer for more but, again, the best and most cost-effective approach is to sanction the offending user(s). Be sure that your Terms of Service specifically forbids what they are doing, though.