I came across this question as I faced a similar issue. The answer is correct that CI doesn't support prepared statements. However it doesn't mean that you can't use prepared statements!
In the following example I am using PDO as my connection class but the following code will work:
$q = $this->db->conn_id->prepare('SELECT * FROM tbl_user WHERE uid=? and activation_key=?');
$q->execute(array($param1,$param2));
print_r($q->fetchAll());
Note the conn_id is the PDO object against which you can run your prepared statements.
What this won't allow however is for you to get the query string which the native CI functions allow. You will need something like Get Last Executed Query in PHP PDO for that.
Further more however this doesn't stop you using the Query Builder to build your statements which you can then use in the PDO prepare. For example -
$db->where('uid = ?',null,false);
$db->where('activation_key = ?',null,false);
$q = $this->db->conn_id->prepare($db->get_compiled_select('tbl_user'));
Would build the query and would allow you to see the basic query if you output $db->get_compiled_select('tbl_user');
As @site80443 points out, CI4 now supports prepared statements and this can be found here:
https://codeigniter.com/user_guide/database/queries.html?highlight=prepared#prepared-queries