I am planning to have a multi server architecture in amazon EC2 where the servers need to talk to each other. These servers need to be located in different amazon regions (different datacenters). Can I just use the internal network of the amazon ec2? What are the security issues? Should I mandatorily use Amazon VPC in this setup.
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Jam ,
If you are planning to create instances on different regions then go for VPC ,because VPC gives you more security .You can restrict these machines for limited external access also . As security part , VPC is better than classic EC2 instances ,as you can even only allow VPC to VPC connections also .

mbdvg
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Thanks. I saw that per region I can create only one vpc, how does the different vpc's talk to each other ? – jam Apr 03 '13 at 12:27
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jam , you can follow the link http://aws.amazon.com/articles/0639686206802544#_Toc331614404 for more ino , it solves your problem – mbdvg Apr 03 '13 at 15:34