The SmtpClient Class states that instance members are not thread safe. This can be seen if concurrent calls are made to Send or SendAsync. Both methods will throw a InvalidOperationException on the second call if the first has not yet completed.
The method SendMailAsync, introduced in .NET 4.5, does not list InvalidOperationException as a thrown exception. Do the new .NET 4.5 methods implement some sort of queuing? Reflector isn't able to shed any light on the implementation details of this class, so I assume this has been implemented in native methods.
Can multiple threads call the SendMessageAsync method on a shared instance of the SMTP client safely?