List comprehension always creates another list, so it's not useful in combining them (e.g. to give a single number). Also, there's no way to make an assignment in list comprehension, unless you're super sneaky.
The only time I'd ever see using list comprehensions as being useful for a sum method is if you only want to include specific values in the list, or you don't have a list of numbers:
list = [1,2,3,4,5]
product = [i for i in list if i % 2 ==0] # only sum even numbers in the list
print sum(product)
or another example":
# list of the cost of fruits in pence
list = [("apple", 55), ("orange", 60), ("pineapple", 140), ("lemon", 80)]
product = [price for fruit, price in list]
print sum(product)
Super sneaky way to make an assignment in a list comprehension
dict = {"val":0}
list = [1, 2, 3]
product = [dict.update({"val" : dict["val"]*i}) for i in list]
print dict["val"] # it'll give you 6!
...but that's horrible :)