If you are willing to use csv format (has obvious limitations) you can use Python's built in CSV library.
Here is a short reader example:
>>> import csv
>>> with open('eggs.csv', 'rb') as csvfile:
... spamreader = csv.reader(csvfile, delimiter=' ', quotechar='|')
... for row in spamreader:
... print ', '.join(row)
Spam, Spam, Spam, Spam, Spam, Baked Beans
Spam, Lovely Spam, Wonderful Spam
Writer example:
import csv
with open('eggs.csv', 'a') as csvfile:
spamwriter = csv.writer(csvfile, delimiter=',',
quotechar='|', quoting=csv.QUOTE_MINIMAL)
spamwriter.writerow(['Spam'] * 5 + ['Baked Beans'])
spamwriter.writerow(['Spam', 'Lovely Spam', 'Wonderful Spam'])
Keep in mind with csv, you can only modify spreadsheet data, no fancy graphs or anything.