awk '
NR==FNR { # IF this is the first file in the arg list THEN
list[$0] # store the contents of the current record as an index or array "list"
next # skip the rest of the script and so move on to the next input record
} # ENDIF
{ # This MUST be the second file in the arg list
for (i in list) # FOR each index "i" in array "list" DO
if (index($0,i) == 1) # IF "i" starts at the 1st char on the current record THEN
next # move on to the next input record
}
1 # Specify a true condition and so invoke the default action of printing the current record.
' file1 file2
An alternative approach to building up an array and then doing a string comparison on each element would be to build up a Regular Expression, e.g.:
...
list = list "|" $0
...
and then doing an RE comparison:
...
if ($0 ~ list)
next
...
but I'm not sure that'd be any faster than the loop and you'd then have to worry about RE metacharacters appearing in file1.
If all of your values in file1 are truly single characters, though, then this approach of creating a character list to use in an RE comparison might work well for you:
awk 'NR==FNR{list = list $0; next} $0 !~ "^[" list "]"' file1 file2