I'd suggest that if you can, you get in touch with MathWorks to ask them for some advice. If you're not able to do that, then I would suggest really reading through the documentation and trying everything you find before giving up.
I've found that a few small changes to the way one implements the MATLAB code, and a few small changes to the project settings (such as disabling responsiveness to Ctrl-C, extrinsic calls back to MATLAB) can make give a speed difference of an order of magnitude or more in the generated code. There are not many people outside MathWorks who would be able to give good advice on exactly what changes might be worthwhile/sensible for you.
I should say that I've only used MATLAB Coder on one project, and I'm not at all an expert (actually not even a competent) C programmer. Nevertheless I've managed to produce C code that was about 10-15 times as fast as the original MATLAB code when mexed. I achieved that by a) just fiddling with all the different settings to see what happened and b) methodically going through the documentation, and seeing if there were places in my MATLAB code where I could apply any of the constructs I came across (such as coder.nullcopy
, coder.unroll
etc). Of course, your code may differ substantially.