If your issue is neither Autolayout related, or the others listed here, there is also another possible problem that turned out to be my issue. I'm simultaneously running a UIView transition (transitionFromView:toView:) on views that take up the same screen space (Different superviews, not related, other than positioning in the superview of the overarching view controller).
My code looked like this:
[UIView transitionFromView:self.someView
toView:self.someOtherView
duration:0.6f
options:UIViewAnimationOptionTransitionCrossDissolve | UIViewAnimationOptionShowHideTransitionViews
completion:NULL];
[UIView animateWithDuration:0.3
delay:0.0 options:UIViewAnimationOptionCurveEaseOut
animations:^{
[self.someThirdView setFrame:someFrame]; //not working
[self.someThirdView setAlpha:1.0f]; //working
} completion:nil];
The frame changed, but it popped to the new frame rather than animating. I'm guessing this is an internal iOS issue. As soon as I removed the "transitionFromView:..." call, the frame animation worked fine.
My solution for now has been to move the second animation into the completion block of the transitionFromView. It's not perfect, as the two animations should have lined up, but it is a passable solution for now.