Yes, you generally have a single HTML page that acts as a "shell" that has views of information loaded into that "shell". The JavaScript files act as the medium to call out to get this data, parse the data and apply templates to the data. Models, controllers, etc. allow for a module approach to the JavaScript structure, as opposed to spaghetti JavaScript code. CSS serves the same purpose as usual.
In my opinion, it is what pure AJAX applications were intended to be about 10 years ago, where a single page would load and then only requests to the server or services would load data, only performing partial page updates instead of posting back to the server to render (or re-render) the page (like WebForms does).
UPDATE:
The Single Page Application: KnockoutJS template incorporates KnockoutJS, but there are other options as detailed in Know a library other than Knockout?, which enumerates the features of each template in a grid for easy viewing.