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This is more an update to this thread: Does Django scale?

Since it's not very clear and seemingly a popular question that people want to know, let's say I have an idea for an app, and I have a potential user-base that would be interacting more or less in a real-time fashion with my site/app. I'd expect if it got popular that I'd need to handle ~100,000 concurrent users.

So, to more or less update the other thread...

  • Could Django/Apache/mod_wsgi handle something like this if configured and optimized correctly? Not 100,000 users per day, but per second?
  • Could something like this be hosted in EC2? What kind of instances would you use? What infrastructures are best suited to something like this now?
  • What type of polling mechanism would you implement?
  • What is the best scalable stack, Apache/mod_wsgi? nginx? Twisted? Comet? Websockets?
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