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Acrobat Reader, Pro, Standard, 3D, etc? What version? Do you need Acrobat specifically? A PDF editor? A PDF viewer?
If you're not picky and are just looking for Acrobat Reader/Pro/Std, I'd start with the HKEY_LOCAL_MACHINE\SOFTWARE\Classes\AcroExch.Document
registry key.
If you're only concerned with a PDF application in general (Adobe, Foxit, Nitro PDF, etc, etc) then start with the HKCR\.pdf
registry key.

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