Here's how you create a Firefox profile:
fp = webdriver.FirefoxProfile()
fp.set_preference("browser.download.folderList",2)
fp.set_preference("browser.download.dir", download_dir)
fp.set_preference("browser.download.manager.showWhenStarting",False)
fp.set_preference("browser.helperApps.neverAsk.saveToDisk","text/csv")
How do you do it with PhantomJS (GhostDriver)?