If you want to extract set of values given a sequence of row labels and column labels, and the lookup method allows for this and returns a numpy array.
Here is my snippet and output:
>>> import pandas as pd
>>> import numpy as np
>>> df = DataFrame(np.random.rand(20,4), columns = ['A','B','C','D'])
>>> df
A B C D
0 0.121190 0.360813 0.500082 0.817546
1 0.304313 0.773412 0.902835 0.440485
2 0.700338 0.733342 0.196394 0.364041
3 0.385534 0.078589 0.181256 0.440475
4 0.151840 0.956841 0.422713 0.018626
5 0.995875 0.110973 0.149234 0.543029
6 0.274740 0.745955 0.420808 0.020774
7 0.305654 0.580817 0.580476 0.210345
8 0.726075 0.801743 0.562489 0.367190
9 0.567987 0.591544 0.523653 0.133099
10 0.795625 0.163556 0.594703 0.208612
11 0.977728 0.751709 0.976577 0.439014
12 0.967853 0.214956 0.126942 0.293847
13 0.189418 0.019772 0.618112 0.643358
14 0.526221 0.276373 0.947315 0.792088
15 0.714835 0.782455 0.043654 0.966490
16 0.760602 0.487120 0.747248 0.982081
17 0.050449 0.666720 0.835464 0.522671
18 0.382314 0.146728 0.666722 0.573501
19 0.392152 0.195802 0.919299 0.181929
>>> df.lookup([0,2,4,6], ['B', 'C', 'A','D'])
array([ 0.36081287, 0.19639367, 0.15184046, 0.02077381])
>>> df.lookup([0,2,4,6], ['A', 'B', 'C','D'])
array([ 0.12119047, 0.73334194, 0.4227131 , 0.02077381])
>>>