I've been able to create objects that are created at every request from this link: http://flask.pocoo.org/docs/appcontext/#locality-of-the-context.
I'm actually creating an API based off of http://blog.miguelgrinberg.com/post/designing-a-restful-api-using-flask-restful.
I want to be able to load an object once and just have it return a processed response rather than it loading at every request. The object is not a DB, just requires unpickling a large file.
I've looked through the documentation, but I'm still confused about this whole Flask two states thing.