I believe the following should work for you.
Event.includes(users: :profile)
If you want to include an association (we'll call it C) of an already included association (we'll call it B), you'd use the syntax above. However, if you'd like to include D as well, which is also an association of B, that's when you'd use the array as given in the example in the Rails Guide.
A.includes(bees: [
:cees,
:dees
])
You could continue to nest includes like that (if you actually need to). Say that A is also associated with Z, and that C is associated to E and F.
A.includes({
bees: [{
cees: [:ees, :effs]
}, :dees]
}, :zees)
And for good fun, we'll also say that E is associated to J and X, and that D is associated to Y.
A.includes({
bees: [{
cees: [{
ees: [:jays, :exes]
}, :effs]
},
{
dees: :wise
}
]
}, :zees)