Looks like somebody is working with radiosondes...
When I pull in my radiosonde data I usually put it in a multi-level indexed dataframe. The levels could be of various forms and orders, but something like FLIGHT_NUM, DATE, ALTITUDE, etc. would make sense. Also, when working with sonde data I too want some additional information that does not necessarily need to be stored within the dataframe, so I store that as additional attributes. If I were to parse your file and then store it I would do something along the lines of this (yes, there are modifications that can be made to "improve" this):
import pandas as pd
with open("filename.csv",'r') as data:
header = data.read().split('\n')[:5] # change to match number of your header rows
data = pd.read_csv(data, skiprows=6, skipinitialspace=True, na_values=[-999,'Infinity','-Infinity'])
# now you can parse your header to get out the necessary information
# continue until you have all the header info you want/need; e.g.
flight = header[0].split(': ')[1]
date = header[1].split(': ')[1].split('')[0]
time = header[1].split(': ')[2]
# a lot of the header information will get stored as metadata for me.
# most likely you want more than flight number and date in your metadata, but you get the point.
data.metadata = {'flight':flight,
'date':date}
I presume you have a date/time column (call it "dates" here) within your file, so you can use that to re-index your dataframe. If you choose to use different variables within your multi-level index then the same method applies.
new_index = [(data.metadata['flight'],r) for r in data.dates]
data.index = pd.MultiIndex.from_tuples(new_index)
You now have a multi-level indexed dataframe.
Now, regarding your "metadata". EdChum makes an excellent point that if you copy "data" you will NOT copy over the metadata dictionary. Also, if you save "data" to a dataframe via data.to_pickle you will lose your metadata (more on this later). If you want to keep your metadata you have a couple options.
Save the data on a flight-by-flight basis. This will allow you to store metadata for each individual flight's file.
Assuming you want to have multiple flights within one saved file: you can add an additional column within your dataframe that hold that information (i.e. another column for flight number, another column for surface temperature, etc.), though this will increase the size of your saved file.
Assuming you want to have multiple flights within one saved file (option 2): You can make your metadata dictionary "keyed" by flight number. e.g.
data.metadata = {FLIGHT1:{'date':date},
FLIGHT2:{'date':date}}
Now to store the metadata. Check you my IO class on storing additional attributes within an h5 file posted here.
Your question was quite broad, so you got a broad answer. I hope this was helpful.