Sure, just use string slicing:
>>> s = "abcdefghijklmnopqrstuvwxyz"
>>> s[1:] + s[:1]
'bcdefghijklmnopqrstuvwxyza'
Basically, the operation you want to do is analogous to rotating the position of the characters by one place to the left. So, we can simply take the part of string after the first character, and add the first character to it.
EDIT: I assumed that OP is asking to rotate a string (which is plausible from his given input, the input string has 26 characters, and he might have been doing a manual replace for each character), in case the post is about creating a cipher, please check @Martjin's answer above.