Even after following the advice in one of the comments here (Create on NOT MATCH command for Neo4j's CQL?) to set allow_store_upgrade to true in conf/neo4j.properties, I was not able to successfully upgrade to 2.2.1
The documentation does not explain how to here either: http://neo4j.com/docs/2.2.1/deployment-upgrading.html
Can anyone shed light on this?