It doesn't appear Workbook is an exported method of "xlsx". In fact, the whole library doesn't appear to support creating a file from scratch. I did find this posting that could be quite helpful to you: How to create an Excel File with Nodejs?
Taking from that, I'd recommend first trying the second answer, installing the node package "msexcel-builder" which looks like it's does what the accepted answer does but with less file write streaming work on your part.
Alternatively, using that posting's accepted answer, you could modify it a bit to:
var fs = require('fs');
var writeStream = fs.createWriteStream("file.xls");
writeStream.close();
var Excel = require("xlsx");
var workbook = Excel.readFile('file.xls');
Excel.writeFile(workbook, 'out.xlsx');