Like this, provided there is one DESC-SEQNUM each:
SELECT DESC, S1.INSTRUCTION, S2.INSTRUCTION, S3.INSTRUCTION
FROM TABLE AS S1 INNER JOIN
TABLE AS S2 ON S1.DESC = S2.DESC
INNER JOIN TABLE AS S3 ON S3.DESC=S1.DESC
For Access SQL you may need to enclose the INNER JOINs like mentioned here:
SQL multiple join statement
The result for Access SQL would be:
SELECT DESC, S1.INSTRUCTION, S2.INSTRUCTION, S3.INSTRUCTION
FROM (TABLE AS S1 INNER JOIN
TABLE AS S2 ON S1.DESC = S2.DESC)
INNER JOIN TABLE AS S3 ON S3.DESC=S1.DESC
As mentioned in the comments this assumes that there are not missing allocations to DESC. If there would be you would need to change the INNER JOINs to LEFT JOINs like this:
SELECT DESC, S1.INSTRUCTION, S2.INSTRUCTION, S3.INSTRUCTION
FROM (TABLE AS S1 LEFT JOIN
TABLE AS S2 ON S1.DESC = S2.DESC)
LEFT JOIN TABLE AS S3 ON S3.DESC=S1.DESC