Can anyone tell me if Microsoft .NET Framework 4.5 is compatible with Windows Server 2003 or not?
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No. .NET 4 is the last framework version supported on Windows Server 2003. .NET 4.5 and higher are not supported on Windows Server 2003.
See .NET Framework Versions and Dependencies for more information.

Bernhard
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Does this mean that if I built an application (Windows Form or Windows Service) targeting .NET Framework 4.5, it will fail to run, even if both .NET Framework 4 and 4.5 use CLR 4? – MaxiWheat Sep 20 '19 at 18:55