To convert the cell reference to a column index you could use something like the following (I've converted the code from the answer here which you've inspired me to write :)).
Private Shared Function GetColumnIndex(cellReference As String) As System.Nullable(Of Integer)
If String.IsNullOrEmpty(cellReference) Then
Return Nothing
End If
'remove digits
Dim columnReference As String = Regex.Replace(cellReference.ToUpper(), "[\d]", String.Empty)
Dim columnNumber As Integer = -1
Dim mulitplier As Integer = 1
'working from the end of the letters take the ASCII code less 64 (so A = 1, B =2...etc)
'then multiply that number by our multiplier (which starts at 1)
'multiply our multiplier by 26 as there are 26 letters
For Each c As Char In columnReference.ToCharArray().Reverse()
columnNumber += mulitplier * (CInt(c) - 64)
mulitplier = mulitplier * 26
Next
'the result is zero based so return columnnumber + 1 for a 1 based answer
'this will match Excel's COLUMN function
Return columnNumber + 1
End Function
Note: the VB might not be idiomatic as I used the Telerik Converter to convert it from C# to VB.