The nodeffi seems to be simplest way to do that.
I didn't test it so it can has problems that I don't realize now.
But I would suggest to do something like that, following the tutorial.
Install nodeffi:
Generate a library for your bus-driver if you don't have one, let's call it libbusdriver.
Then in your javascript do something similar to this:
var ffi = require('ffi');
var libbusdriver = ffi.Library('libbusdriver', {
'bus_init': [ 'void', [ 'void' ] ],
'bus_write': [ 'void', [ 'string' ] ],
});
libbusdriver.bus_init();
libbusdriver.bus_write("Hello");
Let me know if it helps.