Here is a snippet I used to do this.
private void EditAccess(List<string> userlist, string folder)
{
foreach (string user in userlist)
{
var AccessRule = new FileSystemAccessRule(user, FileSystemRights.FullControl,
InheritanceFlags.None,
PropagationFlags.NoPropagateInherit,
AccessControlType.Allow);
DirectoryInfo rootFolder = new DirectoryInfo(folder);
DirectorySecurity rootSec = rootFolder.GetAccessControl(AccessControlSections.Access);
bool Result;
rootSec.ModifyAccessRule(AccessControlModification.Set, AccessRule, out Result);
InheritanceFlags iFlags = InheritanceFlags.ContainerInherit | InheritanceFlags.ObjectInherit;
AccessRule = new FileSystemAccessRule(user, FileSystemRights.FullControl, iFlags, PropagationFlags.InheritOnly, AccessControlType.Allow);
rootSec.ModifyAccessRule(AccessControlModification.Add, AccessRule, out Result);
rootFolder.SetAccessControl(rootSec);
}
}