According to this API doc, which is the only source I've found which describes the in-memory cache:
Chrome employs two caches — an on-disk cache and a very fast in-memory cache. The lifetime of an in-memory cache is attached to the lifetime of a render process, which roughly corresponds to a tab. Requests that are answered from the in-memory cache are invisible to the web request API. If a request handler changes its behavior (for example, the behavior according to which requests are blocked), a simple page refresh might not respect this changed behavior. To make sure the behavior change goes through, call handlerBehaviorChanged() to flush the in-memory cache. But don't do it often; flushing the cache is a very expensive operation. You don't need to call handlerBehaviorChanged() after registering or unregistering an event listener.
I need a better understanding of the in-memory cache. Specifically, I need Chrome to generate the full webRequest / resource waterfall every time I visit a site, including refreshing a page. Obviously, this can't be true if it's using an in-memory cache.
Is the memory cache a clean-slate for a new tab when I create a new tab?
What does "very expensive operation" mean quantitatively?
If I call handlerBehaviorChanged() every time a page is reloaded in the same tab, will that guarantee a full waterfall? In that case, a limit of 20 times over 10 minutes seems fairly low.
Any help is highly appreciated, thanks!