You could loop through every node in your matrix and then add every neighboring node at right & below to the result:
matrix = [
['A', 'B', 'C', 'D'],
['E', 'F', 'G', 'H'],
['I', 'J', 'K', 'L'],
['M', 'N', 'O', 'P']
]
def add(adj_list, a, b):
adj_list.setdefault(a, []).append(b)
adj_list.setdefault(b, []).append(a)
adj_list = {}
for i in range(len(matrix)):
for j in range(len(matrix[i])):
if j < len(matrix[i]) - 1:
add(adj_list, matrix[i][j], matrix[i][j+1])
if i < len(matrix[i]) - 1:
for x in range(max(0, j - 1), min(len(matrix[i+1]), j+2)):
add(adj_list, matrix[i][j], matrix[i+1][x])
import pprint
pprint.pprint(adj_list)
Output:
{'A': ['B', 'E', 'F'],
'B': ['A', 'C', 'E', 'F', 'G'],
'C': ['B', 'D', 'F', 'G', 'H'],
'D': ['C', 'G', 'H'],
'E': ['A', 'B', 'F', 'I', 'J'],
'F': ['A', 'B', 'C', 'E', 'G', 'I', 'J', 'K'],
'G': ['B', 'C', 'D', 'F', 'H', 'J', 'K', 'L'],
'H': ['C', 'D', 'G', 'K', 'L'],
'I': ['E', 'F', 'J', 'M', 'N'],
'J': ['E', 'F', 'G', 'I', 'K', 'M', 'N', 'O'],
'K': ['F', 'G', 'H', 'J', 'L', 'N', 'O', 'P'],
'L': ['G', 'H', 'K', 'O', 'P'],
'M': ['I', 'J', 'N'],
'N': ['I', 'J', 'K', 'M', 'O'],
'O': ['J', 'K', 'L', 'N', 'P'],
'P': ['K', 'L', 'O']}