What type of gaming do you want to protect yourself against? Someone creating a couple of bots and bombing you with thousands (millions) of requests? Or someone with no better things to do and try to make 10-20 votes?
Yes, I know: both - but which one is your main concern in here?
Using CAPTCHA together with email based voting (send a link to the email to validate the vote) might work well against bots. But a human can more or less easily exploit the email system (as I comment in one answer and post here again)
I own a custom domain and I can have any email I want within it.
Another example: if your email is
myuser*@gmail.com*, you could use
"myuser+1@gmail.com"
myuser+2@gmail.com, etc (the plus sign and the text after
it are ignored and it is delivered
to your account). You can also include
dots in your username (my.user@gmail.com). (This only
works on gmail addresses!)
To protect against humans, I don't know ever-cookie but it might be a good choice. Using OAuth integrated with twitter, FB and other networks might also work well.
Also, remember: requiring emails for someone to vote will scare many people off! You will get many less votes!
Another option is to limit the number of votes your system accepts from each ip per minute (or hour or anything else). To protect against distributed attacks, limit the total number of votes your system accepts within a timeframe.