How to pass a list of lists through a for loop in Python?

Question

I have a list of lists :

sample = [['TTTT', 'CCCZ'], ['ATTA', 'CZZC']]
count = [[4,3],[4,2]]
correctionfactor  = [[1.33, 1.5],[1.33,2]]

I calculate frequency of each character (pi), square it and then sum (and then I calculate het = 1 - sum).

The desired output [[1,2],[1,2]] #NOTE: This is NOT the real values of expected output. I just need the real values to be in this format. 

The problem: I do not how to pass the list of lists(sample, count) in this loop to extract the values needed. I previously passed only a list (eg ['TACT','TTTT'..]) using this code.

• I suspect that I need to add a larger for loop, that indexes over each element in sample (i.e. indexes over sample[0] = ['TTTT', 'CCCZ'] and sample[1] = ['ATTA', 'CZZC']. I am not sure how to incorporate that into the code.

** Code

list_of_hets = []
for idx, element in enumerate(sample):
    count_dict = {}
    square_dict = {}
    for base in list(element):
         if base in count_dict:
            count_dict[base] += 1
        else:
            count_dict[base] = 1
    for allele in count_dict: #Calculate frequency of every character
        square_freq = (count_dict[allele] / count[idx])**2 #Square the frequencies
        square_dict[allele] = square_freq        
    pf = 0.0
    for i in square_dict:
        pf += square_dict[i]   # pf --> pi^2 + pj^2...pn^2 #Sum the frequencies
    het = 1-pf                    
    list_of_hets.append(het)
print list_of_hets

"Failed" OUTPUT:
line 70, in <module>
square_freq = (count_dict[allele] / count[idx])**2
TypeError: unsupported operand type(s) for /: 'int' and 'list'er

Answer 1

I'm not completely clear on how you want to handle the 'Z' items in your data, but this code replicates the output for the sample data in https://eval.in/658468

from __future__ import division

bases = set('ACGT')
#sample = [['TTTT', 'CCCZ'], ['ATTA', 'CZZC']]
sample = [['ATTA', 'TTGA'], ['TTCA', 'TTTA']]

list_of_hets = []
for element in sample:
    hets = []
    for seq in element:
        count_dict = {}
        for base in seq:
            if base in count_dict:
                count_dict[base] += 1
            else:
                count_dict[base] = 1
        print count_dict

        #Calculate frequency of every character
        count = sum(1 for u in seq if u in bases)
        pf = sum((base / count) ** 2 for base in count_dict.values())
        hets.append(1 - pf)
    list_of_hets.append(hets)

print list_of_hets

output

{'A': 2, 'T': 2}
{'A': 1, 'T': 2, 'G': 1}
{'A': 1, 'C': 1, 'T': 2}
{'A': 1, 'T': 3}
[[0.5, 0.625], [0.625, 0.375]]

This code could be simplified further by using a collections.Counter instead of the count_dict.

BTW, if the symbol that's not in 'ACGT' is always 'Z' then we can speed up the count calculation. Get rid of bases = set('ACGT') and change

count = sum(1 for u in seq if u in bases)

to

count = sum(1 for u in seq if u != 'Z')