use the second one,it is sargable and can use indexes if present
EventStartDateTime < DATEADD(DY, -60, GETDATE())
Also WHERE
clause is not the only place where Sargabilty matters.it can also have an effect on ORDER BY, GROUP BY and HAVING clauses.
And is there a way to measure this in the future to test for myself?
You can look at the execution plan ,to see if it is doing a seek or Scan.
This doesn't mean seek is good or scan is bad.when you have index and it is Sargable,it will try* to seek the value,rather than scanning the whole table
Please see below link which has more details on same,as pointed by @AdatheDev in comments..
Is this date comparison condition SARG-able in SQL?