Any of , (comma) ; (semi-colon) <> (angle brackets) [] (square brackets) or " (double quote) should work for most cases.
Since these characters are allowed in quoted strings, you could replace the "@" with a sequence that would be invalid such as three double quotes in a row.
According to the RFC
within a quoted string, any ASCII graphic or space is permitted without blackslash-quoting except double-quote and the backslash itself.
You could have an email abc."~~~".def@rst.xyz. But you could not have abc.""".def@rst.xyz; it would have to be abc.""".def@rst.xyz. So you could safely use """ as a substitute for @ in the filename.
However, the RFC also says
While the above definition for Local-part is relatively permissive,
for maximum interoperability, a host that expects to receive mail
SHOULD avoid defining mailboxes where the Local-part requires (or
uses) the Quoted-string form or where the Local-part is case-
sensitive.
With SHOULD meaning "...that
there may exist valid reasons in particular circumstances when the
particular behavior is acceptable or even useful, but the full
implications should be understood and the case carefully weighed
before implementing..." RFC2119
So, although """ will work, are the chances you will see an email with quotes worth the trouble of designing for it? If not, then use one of the single characters.