Printing to Dymo Labelmaker with Python on OS X

Question

Part of my job is to print several hundred labels per day with a Dymo labelwriter. We use macOS for everything, and installing Windows is out of the question as it would break tons of workflow. We have a template file that I can modify using Python's xml.etree module. How would I print the labels to our labelwriter using solely Python? I've read up on using os.system to send the data straight to the printer, but I'm not sure how that would work with an XML file and a labelwriter, which seems incredibly proprietary. I don't mind using other languages or APIs as long as they're easy to explain to the non-technical people in the office. Also open to using AppleScript.