If you are working with a ML program, there are several methods. If you aren't worried about ever returning to normal READY prompt without a RESET, you can have a small loader that loads into the stack ($0100-$01FF) The loader would just load the next section of code, then jump to it. It would start at $0102 and needs to be as small as possible. Many times, the next piece to load is only 2 characters, so the file name can be placed at $0100 & $0101. Then all you need to do is set LFS, SETNAM, LOAD, then JMP to it. Fill the rest of the stack area with $01. It is also rather safe to only save $0100-$010d so that the entire program will fit on a single disk block.
One issue with this, is that it clears out past stack entries (so, your program will need to reset the stack pointer back to the top.) If your program tries to do a normal RTS out of itself, random things can occur. If you want to exit the program, you'll need to jmp to the reset vector ($FFFC by default,) to do so.