Things I am aware of:
Screen flicker if scripts alter styles / content (not an issue for me as I currently load scripts at the end of the page and so have workarounds already)
Inability to detect script load failure (not too concerned about this either as everything I develop is required to work with or without javascript. Might affect my workarounds for item 1 but happy with this risk)
It looks to be a very good option to me but I am hoping for some references (feel free to say only positive things!) before I invest time in incorporating it into my next project.
Currently we develop mid-to-large sized sites with, generally, a moderate amount of Javascript (although this is growing rapidly). We also use the jQuery library for the bulk of our Javascript.
Anyone have any experience? Good or bad! :)
P.S. for those interested this is head.js