The code the compiler generates for both code snippets will be identical, so the only remaining concern is maintainability of the resulting code.
As far as maintainability is concerned, the main difference is that the "ungrouped" approach lets you write documentation comments for each individual variable, i.e.
/// <summary>Red color component</summary>
private int red;
/// <summary>Green color component</summary>
private int green;
/// <summary>Blue color component</summary>
private int blue;
while the "grouped" approach lets you specify a single documentation comment for the entire group:
/// <summary>RGB color components</summary>
private int red, green, blue;
Neither approach is better than the other; they are just different.