I'm using Sikuli (sikulixapi-1.1.0).
I have 2 monitors. When I use my primary monitor, everything is ok. When I also use the second monitor, it does not work.
I make a screenshot on the second monitor and I wrote this:
Screen s = new Screen(1);
Error
Possible cause in case you did not touch the mouse while script was running: Mouse actions are blocked generally or by the frontmost application. You might try to run the SikuliX stuff as admin.