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I am running a microarray data analysis, 

raw_data = read.celfiles(....... )
exp_raw <- log2(exprs(raw_data)) 
PCA_raw <- prcomp(t(exp_raw), scale = FALSE)

and I got

Error in La.svd(x, nu, nv) : LAPACK routines cannot be loaded
Besides: Warning message:
In La.svd(x, nu, nv) :
   unable to load share-object'/Library/Frameworks/R.framework/Resources/modules//lapack.so' : `maximal number of DLLs reached...

this is the packages I loaded

library(Biobase, oligoClasses, knitr, BiocStyle, oligo, geneplotter, ggplot2, dplyr, LSD, gplots, RColorBrewer, ArrayExpress, arrayQualityMetrics, stringr, matrixStats, topGO, genefilter, pd.hugene.1.0.st.v1, hugene10sttranscriptcluster.db, pheatmap, mvtnorm, DAAG, multcomp, limma, ReactomePA, clusterProfiler, openxlsx, devtools, biomaRt, EnrichmentBrowser)

my session info

setting  value                       
 version  R version 3.4.1 (2017-06-30)
 system   x86_64, darwin15.6.0        
 ui       RStudio (1.0.153)           
 language (EN)                        
 collate  zh_TW.UTF-8                 
 date     2017-10-03

Can someone tell me how to fix this?

zx8754
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pill45
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  • As a possible work-around, separate your code into two scripts: one that loads, wrangles the data and then exports the result to an `.RData` file; and the second script that loads that `.RData` and performs PCA without also loading all the other unnecessary packages. – Artem Sokolov Oct 03 '17 at 15:41
  • It works. But is it the DLL thinks? What if I changed the R environment to using R_MAX_NUM_DLLS ? – pill45 Oct 03 '17 at 18:25
  • Possible duplicate of [Error: Maximal number of DLLs reached](https://stackoverflow.com/questions/36974206/error-maximal-number-of-dlls-reached) – Artem Sokolov Oct 05 '17 at 14:08

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