If what you're trying to do is determine if two numbers are practically equivalent you'll have to come up with your margin of error. One way to do this is to compute the difference between the numbers and then determine if that difference is significant or not.
So, taking your numbers from before, we could evaluate the difference between these numbers through subtraction. Since we don't really care about the sign of this difference, I'll go ahead and get the absolute value of the difference.
Math.abs(4.0329146112660565e+26 - 4.0329146112661e+26) === 4329327034368
(Sidenote: Now is not the time to explain why, but the == operator in JavaScript has confusing and error-prone behavior, use === when you want to compare values.)
That difference is a HUGE number, but related to how big our numbers are in the first place, it's rather insignificant. Intuitively, I'm tempted to divide the difference by the smallest of our original numbers like so:
4329327034368 / 4.0329146112660565e+26 === 1.0734983136696987e-14
That looks like a pretty small number. Repeat that same operation with a bunch of values and you should be able to determine what you want your margin of error to be. Then, all you'll have to do is perform the same operations with arbitrary numbers and see if that "difference ratio" is small enough for you.
function similar(a, b) {
let diff = Math.abs(a - b);
let smallest = Math.min(Math.abs(a), Math.abs(b));
let ratio = diff / smallest;
return ratio < MARGIN_OF_ERROR;
}
Now I just came up with that way of determining the importance of the difference between two numbers. It might not be a very smart way to compute it, it might be appropriate to some situations and not to others. But the general idea is that you'll have to make a function that determines if two values are close enough with your own definition of "close".
Be aware though, JavaScript is one of the worst languages you can be doing math in. Integers become imprecise when they go beyond Number.MAX_SAFE_INT (which seems to be 9007199254740991 according to Chrome, not sure if it varies between browsers or if that's a standardized constant).